Fault Tolerant Scheduling of Partitioned and Grouped Jobs in Grid Computing (FTPG)

Computational grids have the potential for solving scientific and large - scale problems using heterogeneous and geographically distributed resources In addition to the challenges of managing and scheduling resources reliable challenges arise because the grid infrastructure is unreliable There are two major problems in Scheduling the Grid 1 Efficient Scheduling of jobs 2 Providing fault tolerance in a reliable manner Most of the existing strategies do not provide fault tolerance There are some algorithms which provide fault tolerance but they do a large amount of redundant computation to provide fault tolerance This paper addresses this issue and minimizes redundant work by using a group level table of data This technique is suitable for partitioning and group scheduling of job

Sterile inflammation enhances ECM degradation in integrin β1 KO embryonic skin

Epidermal knockout of integrin β1 results in complete disorganization of the basement membrane (BM), resulting in neonatal lethality. Here, we report that this disorganization is exacerbated by an early embryonic inflammatory response involving the recruitment of tissue-resident and monocyte-derived macrophages to the dermal-epidermal junction, associated with increased matrix metalloproteinase activity. Remarkably, the skin barrier in the integrin β1 knockout animals is intact, suggesting that this inflammatory response is initiated in a sterile environment. We demonstrate that the molecular mechanism involves de novo expression of integrin αvβ6 in the basal epidermal cells, which activates a TGF-β1 driven inflammatory cascade resulting in upregulation of dermal NF-κB in a Tenascin C-dependent manner. Importantly, treatment of β1 KO embryos in utero with small molecule inhibitors of TGF-βR1 and NF-κB results in marked rescue of the BM defects and amelioration of immune response, revealing an unconventional immuno-protective role for integrin β1 during BM remodeling

Optimization of Linear Arrays using Modified Social Group Optimization Algorithm

354-359In this paper, optimization of the linear array (LA) antenna is performed using modified social group optimization algorithm (SGOA). First step of the work involves in transforming the electromagnetic engineering problem to an optimization problem which is completely described in terms of objectives. Linear array synthesis is inherently considered as a multi-attribute problem. The pattern synthesis of LA is carried out with several objectives involving sidelobe level (SLL), beam-width (BW) and desired nulls. The SLL suppression with BW constraint is considered as first objective of this work and the results are compared with several evolutionary computing algorithms like ant lion (ALO), grey wolf (GWO) and root-runner (RRA). Following this, the MSGOA is further used to synthesise null patterns in which the pattern is completely described in terms of nulls with SLL and BW as constraints. The entire simulation-based experimentation is performed using Matlab® on i5 computing system

Nomogram-based Prediction of Overall Survival in Patients with Metastatic Urothelial Carcinoma Receiving First-line Platinum-based Chemotherapy: Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC)

The available prognostic models for overall survival (OS) in patients with metastatic urothelial carcinoma (UC) have been derived from clinical trial populations of cisplatin-treated patients

The effectiveness of a low-intensity problem-solving intervention for common adolescent mental health problems in New Delhi, India: protocol for a school-based, individually randomized controlled trial with an embedded stepped-wedge cluster randomized controlled recruitment trial

Background Conduct, anxiety and depressive disorders account for over 75% of the adolescent mental health burden globally. The current protocol will test a low-intensity problem-solving intervention for school-going adolescents with common mental health problems in India. The protocol also tests the effects of a classroom-based sensitization intervention on the demand for counselling services in an embedded recruitment trial. Methods We will conduct a two-arm individually randomized controlled trial in six Government-run secondary schools in New Delhi. The targeted sample is 240 adolescents in grades 9-12 with persistent, elevated mental health symptoms and associated impact. Participants will receive either a brief problem-solving intervention delivered over 3 weeks by lay counsellors (intervention), or enhanced usual care comprised of problem-solving booklets (control). Self-reported adolescent mental health symptoms and idiographic problems will be assessed at 6 weeks (co-primary outcomes) and again at 12 weeks post-randomization. In addition, adolescent-reported impact of mental health difficulties, perceived stress, mental wellbeing and clinical remission, as well as parent-reported adolescent mental health symptoms and impact scores, will be assessed at 6 and 12 weeks post-randomization. We will also complete a parallel process evaluation, including estimations of the costs of delivering the interventions. An embedded recruitment trial will apply a stepped-wedge, cluster (class)-randomized controlled design in 70 classes across the six schools. This will evaluate the added impact of a classroom-based sensitization intervention over school-level recruitment sensitization activities on the primary outcome of referral rate into the host trial (i.e. the proportion of adolescents referred as a function of the total sampling frame in each condition of the embedded recruitment trial). Other outcomes will be the proportion of referrals eligible to participate in the host trial, proportion of self-generated referrals, and severity and pattern of symptoms among referred adolescents in each condition. Power calculations were undertaken separately for each trial. A detailed statistical analysis plan will be developed separately for each trial prior to unblinding. Discussion Both trials were initiated on 20 August 2018. A single research protocol for both trials offers a resource-efficient methodology for testing the effectiveness of linked procedures to enhance uptake and outcomes of a school-based psychological intervention for common adolescent mental health problems

Promotion, prevention and protection: interventions at the population- and community-levels for mental, neurological and substance use disorders in low- and middle-income countries

Background In addition to services within the health system, interventions at the population and community levels are also important for the promotion of mental health, primary prevention of mental, neurological and substance use (MNS) disorders, identification and case detection of MNS disorders; and to a lesser degree treatment, care and rehabilitation. This study aims to identify “best practice” and “good practice” interventions that can feasibly be delivered at these population- and community-levels in low- and middle-income countries (LMICs), to aid the identification of resource efficiencies and allocation in LMICs. Methods A narrative review was conducted given the wide range of relevant interventions. Expert consensus was used to identify “best practice” at the population-level on the basis of existing quasi-experimental natural experiments and cost effectiveness, with small scale emerging and promising evidence comprising “good practice”. At the community-level, using expert consensus, the ACE (Assessing Cost-Effectiveness in Prevention Project) grading system was used to differentiate “best practice” interventions with sufficient evidence from “good practice” interventions with limited but promising evidence. ResultsAt the population-level, laws and regulations to control alcohol demand and restrict access to lethal means of suicide were considered “best practice”. Child protection laws, improved control of neurocysticercosis and mass awareness campaigns were identified as “good practice”. At the community level, socio-emotional learning programmes in schools and parenting programmes during infancy were identified as “best practice”. The following were all identified as “good practice”: Integrating mental health promotion strategies into workplace occupational health and safety policies; mental health information and awareness programmes as well as detection of MNS disorders in schools; early child enrichment/preschool educational programs and parenting programs for children aged 2–14 years; gender equity and/or economic empowerment programs for vulnerable groups; training of gatekeepers to identify people with MNS disorders in the community; and training non-specialist community members at a neighbourhood level to assist with community-based support and rehabilitation of people with mental disorders. Conclusion Interventions provided at the population- and community-levels have an important role to play in promoting mental health, preventing the onset, and protecting those with MNS disorders. The importance of inter-sectoral enga

Cryogen-free low temperature and high magnetic field apparatus

334-338The importance of low temperature and high magnetic field measurements in pure and applied science research cannot be overstated. Traditionally these experiments have been carried out by evaporation of liquefied helium. This is a costly proposition, especially in our country, where maintaining liquid helium plants and the recovery lines has become persistent predicament. In this paper, the possibility of an alternative cost-effective technology based on two stage Gifford-McMahon closed cycle cryocoolers which is most ideally suited for small groups of researchers has been presented. The principle of operation and instrumentation details of a recently installed single compressor 1.6 K, 8 tesla cryocooler has been described

Cryogen-free low temperature and high magnetic field apparatus

The importance of low temperature and high magnetic field measurements in pure and applied science research cannot be overstated. Traditionally these experiments have been carried out by evaporation of liquefied helium. This is a costly proposition, especially in our country, where maintaining liquid helium plants and the recovery lines has become persistent predicament. In this paper, the possibility of an alternative cost-effective technology based on two stage Gifford-McMahon closed cycle cryocoolers which is most ideally suited for small groups of researchers has been presented. The principle of operation and instrumentation details of a recently installed single compressor 1.6 K, 8 tesla cryocooler has been described